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Article

Genetic variations in the host dependency factors ALCAM and TPST2 impact HIV-1 disease progression.

AIDS (London, England) - 15 Jul 2020

Kruize Zita, Maurer Irma, Boeser-Nunnink Brigitte D M, Booiman Thijs, Kootstra Neeltje A

Abstract excerpt

OBJECTIVES: Recently, the activated leukocyte cell adhesion molecule (ALCAM) and tyrosylprotein sulfotransferase 2 (TPST2) have been identified as important host dependency factors (HDFs) for in-vitro HIV-1 replication. To determine whether these genes play a role in HIV-1 pathogenesis, we analysed whether naturally occurring genetic variations were associated with the clinical course of infection....

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PMID: 32287057
DOI: 10.1097/QAD.0000000000002540

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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