Frequency variation among sub-Saharan populations in virus restriction gene, BST-2 proximal promoter polymorphisms: implications for HIV-1 prevalence differences among African countries.

doi:10.1089/omi.2013.0127

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Article

Frequency variation among sub-Saharan populations in virus restriction gene, BST-2 proximal promoter polymorphisms: implications for HIV-1 prevalence differences among African countries.

Omics : a journal of integrative biology - 1 Jul 2014

Skelton Michelle M, Kampira Elizabeth E, Wonkam Ambroise A, Mhandire Kudakwashe K, Kumwenda Johnstone J, Duri Kerina K, Dandara Collet C

Abstract excerpt

The present study reports promoter variants in four sub-Saharan African populations that may affect BST-2 gene regulation. Recently, an in/del within the BST-2 promoter has been associated with HIV-1 disease progression in a Spanish cohort. Hence, we sequenced the proximal promoter region of the BST-2 gene in 581 individuals from South Africa, Zimbabwe, Malawi, and Cameroon. Seven SNPs were identified: rs28413176...

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PMID: 24601767
DOI: 10.1089/omi.2013.0127

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