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Article

The impact of bone marrow stromal antigen-2 (BST2) gene variants on HIV-1 control in black South African individuals.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jun 2020

Dias Bianca Da Costa, Paximadis Maria, Martinson Neil, Chaisson Richard E, Ebrahim Osman, Tiemessen Caroline T

Abstract excerpt

Bone marrow stromal cell antigen 2 (BST2 or tetherin) is a host-encoded, interferon-inducible antiviral restriction factor which blocks the release of enveloped viruses. Few studies have assessed the role of BST2 polymorphisms on HIV-1 acquisition or disease progression in sub-Saharan Africa. This study investigated the frequency of four HIV-1-associated BST2 variants rs3217318, rs12609479, rs10415893 and...

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Share to Antigens, CD
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Source

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Identifiers

PMID: 32006707
DOI: 10.1016/j.meegid.2020.104216
PMCID: PMC8752124

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