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Article

N-acetyltransferase genotypes and the pharmacokinetics and tolerability of para-aminosalicylic acid in patients with drug-resistant pulmonary tuberculosis.

Antimicrobial agents and chemotherapy - 1 Jul 2015

Sy Sherwin K B, de Kock Lizanne, Diacon Andreas H, Werely Cedric J, Xia Huiming, Rosenkranz Bernd, van der Merwe Lize, Donald Peter R

Abstract excerpt

The aim of this study was to examine the relationships between N-acetyltransferase genotypes, pharmacokinetics, and tolerability of granular slow-release para-aminosalicylic acid (GSR-PAS) in tuberculosis patients. The study was a randomized, two-period, open-label, crossover design wherein each patient received 4 g GSR-PAS twice daily or 8 g once daily alternately. The PAS concentration-time profiles were...

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Identifiers

PMID: 25963985
DOI: 10.1128/AAC.04049-14
PMCID: PMC4468703

Genes

NAT1
GSR
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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