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Article

Effect of Genetic Variation of NAT2 on Isoniazid and SLCO1B1 and CES2 on Rifampin Pharmacokinetics in Ghanaian Children with Tuberculosis.

Antimicrobial agents and chemotherapy - 1 Mar 2018

Dompreh Albert, Tang Xiaoli, Zhou Jianlin, Yang Hongmei, Topletz Ariel, Adu Ahwireng Eugene, Antwi Sampson, Enimil Antony, Langaee Taimour, Peloquin Charles A, Court Michael H, Kwara Awewura

Abstract excerpt

Isoniazid and rifampin are essential components of first-line antituberculosis (anti-TB) therapy. Understanding the relationship between genetic factors and the pharmacokinetics of these drugs could be useful in optimizing treatment outcomes, but this is understudied in children. We investigated the relationship between N-acetyltransferase type 2 (NAT2) genotypes and isoniazid pharmacokinetics, as well as that...

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Source

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Identifiers

PMID: 29263072
DOI: 10.1128/AAC.02099-17
PMCID: PMC5826147

Genes

NAT2
CES2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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