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Article

A pilot study to investigate the utility of NAT2 genotype-guided isoniazid monotherapy regimens in NAT2 slow acetylators.

Pharmacogenetics and genomics - 1 Apr 2021

Yoo Hyounggyoon, Chun Ji Sang, Cho Joo-Youn, Kim Sang-Heon, Yoon Jihoon G, Goo Lee Min, Yu Kyung-Sang, Jang In-Jin, Oh Jaeseong

Abstract excerpt

Isoniazid is a therapeutic agent for the treatment of latent tuberculosis infection. Genetic variants in the N-acetyltransferase 2 (NAT2) are associated with the safety and pharmacokinetics of isoniazid. The study aimed to evaluate the safety and pharmacokinetics of a NAT2 genotype-guided regimen of isoniazid monotherapy. A randomized, open-label, parallel-group and multiple-dosing study was performed in healthy...

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Identifiers

PMID: 33165168
DOI: 10.1097/FPC.0000000000000423

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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