Article
Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks.
PLoS genetics - 1 Jan 2013
Holdt Lesca M, Hoffmann Steve, Sass Kristina, Langenberger David, Scholz Markus, Krohn Knut, Finstermeier Knut, Stahringer Anika, Wilfert Wolfgang, Beutner Frank, Gielen Stephan, Schuler Gerhard, Gäbel Gabor, Bergert Hendrik, Bechmann Ingo, Stadler Peter F, Thiery Joachim, Teupser Daniel
Abstract excerpt
The chromosome 9p21 (Chr9p21) locus of coronary artery disease has been identified in the first surge of genome-wide association and is the strongest genetic factor of atherosclerosis known today. Chr9p21 encodes the long non-coding RNA (ncRNA) antisense non-coding RNA in the INK4 locus (ANRIL). ANRIL expression is associated with the Chr9p21 genotype and correlated with atherosclerosis severity. Here, we report...
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