Impact of human D398N single nucleotide polymorphism on intracellular calcium response mediated by α3β4α5 nicotinic acetylcholine receptors.

doi:10.1016/j.neuropharm.2012.07.022

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Article

Impact of human D398N single nucleotide polymorphism on intracellular calcium response mediated by α3β4α5 nicotinic acetylcholine receptors.

Neuropharmacology - 1 Nov 2012

Tammimäki Anne, Herder Penelope, Li Ping, Esch Caroline, Laughlin James R, Akk Gustav, Stitzel Jerry A

Abstract excerpt

The human CHRNA5 D398N polymorphism (rs16969968) causes an aspartic acid to asparagine change in the nicotinic acetylcholine receptor (nAChR) α5 subunit gene. The N398 variant of CHRNA5 is linked to increased risk for nicotine dependence. In this study, we explored the effect of the CHRNA5 D398N polymorphism on the properties of human α3β4* nicotinic acetylcholine receptors in human embryonic kidney (HEK) cells....

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Identifiers

PMID: 22820273
DOI: 10.1016/j.neuropharm.2012.07.022
PMCID: PMC3661904

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CHRNA5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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