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Article

Targeted Mutations Activate Allosteric Modulation of α5-Containing Nicotinic Acetylcholine Receptors.

ACS chemical neuroscience - 17 Jun 2026

Marotta Christopher B, Lester Henry A, Dougherty Dennis A

Abstract excerpt

Nicotinic acetylcholine receptors play vital roles in neuronal communication. The α5 subunit is unique, in that it assembles only into the auxiliary position (the "5th" subunit of the pentamer) of a functional receptor, yet it can have a substantial effect on a receptor's physiological response. In addition, it is expressed in reward and aversive pathways, highlighting its importance in nicotine dependence. The...

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Identifiers

PMID: 42241501
DOI: 10.1021/acschemneuro.6c00267
PMCID: PMC13281387

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