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Article

Role of negatively charged amino acids in beta 4 F-loop in activation and desensitization of alpha 3 beta 4 rat neuronal nicotinic receptors.

Biochimica et biophysica acta - 1 Apr 2008

Lindovský Jirí, Kaniaková Martina, Svobodová Lucie, Vyskocil Frantisek, Krůsek Jan

Abstract excerpt

The role of negatively charged amino acids in the F-loop of the beta 4 subunit in channel activation and desensitization was studied using the patch-clamp technique. The selected amino acids were changed to their neutral analogs via point mutations. Whole-cell currents were recorded in COS cells transiently transfected with the alpha 3 beta 4 nicotinic acetylcholine receptor. The application of acetylcholine...

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Source

Identifiers

PMID: 18249185
DOI: 10.1016/j.bbamem.2008.01.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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