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Article

A CHRNA5 Smoking Risk Variant Decreases the Aversive Effects of Nicotine in Humans.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Nov 2015

Jensen Kevin P, DeVito Elise E, Herman Aryeh I, Valentine Gerald W, Gelernter Joel, Sofuoglu Mehmet

Abstract excerpt

Genome-wide association studies have implicated the CHRNA5-CHRNA3-CHRNB4 gene cluster in risk for heavy smoking and several smoking-related disorders. The heavy smoking risk allele might reduce the aversive effects of nicotine, but this hypothesis has not been tested in humans. We evaluated the effects of a candidate causal variant in CHRNA5, rs16969968, on the acute response to nicotine in European American (EA)...

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Cognition Disorders
Cotinine
Heart Rate
Neuropsychological Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nicotinic Agonists

Receptors, Nicotinic

Substance Withdrawal Syndrome

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Open in PubMed Open full text

Identifiers

PMID: 25948103
DOI: 10.1038/npp.2015.131
PMCID: PMC4864657

Genes

CHRNA5
CHRNA3
CHRNB4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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A CHRNA5 Smoking Risk Variant Decreases the Aversive Effects of Nicotine in Humans.PMID 25948103Read ↗

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The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.Semantic proximity Read ↗

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