Article
Smoking-Related Increases in Alcohol Outcomes and Preliminary Evidence for the Protective Effect of a Functional Nicotine Receptor Gene (CHRNA5) Variant on Alcohol Consumption in Individuals Without Alcohol Use Disorder.
The international journal of neuropsychopharmacology - 1 Oct 2024
Venkatesh Shyamala K, Stangl Bethany L, Yan Jia, Quijano Cardé Natalia A, Stein Elliot A, Diazgranados Nancy, Schwandt Melanie L, Sun Hui, Momenan Reza, Goldman David, De Biasi Mariella, Ramchandani Vijay A
Abstract excerpt
BACKGROUND: Alcohol and nicotine interact with the nicotinic acetylcholine receptor system to alter reward-related responses, thereby contributing to the co-use and misuse of these drugs. A missense polymorphism rs16969968 (G>A) in the CHRNA5 gene has shown a strong association with nicotine-related phenotypes. However, less is known about the impact of this variant on alcohol-related phenotypes. METHODS: We...
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