Article

Exploration of the role of <i>CHRNA5-A3-B4</i> genotype in smoking behaviours

2019-10-25

Abstract excerpt

Genome-wide association studies have identified associations between variation at rs16969968/rs1051730 in the CHRNA5–A3–B4 gene cluster and smoking related outcomes. Experiments in rodents have described the nicotinic acetylcholine receptors (nAChRs) subunits encoded by this gene cluster and showed a lack of nicotine aversion in nAChRs deficient animal models. We conducted a nicotine challenge and a smoking topog...

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Literature Corpus work: d169b897-28bc-50c6-8859-b80c6c5966b5
DOI: 10.1101/818252

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