Article
Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smoking.
Addiction (Abingdon, England) - 1 Sept 2008
Sherva Richard, Wilhelmsen Kirk, Pomerleau Cynthia S, Chasse Scott A, Rice John P, Snedecor Sandy M, Bierut Laura J, Neuman Rosalind J, Pomerleau Ovide F
Abstract excerpt
AIMS: To extend the previously identified association between a single nucleotide polymorphism (SNP) in neuronal acetylcholine receptor subunit alpha-5 (CHRNA5) and nicotine dependence to current smoking and initial smoking-experience phenotypes. DESIGN, SETTING, PARTICIPANTS: Case-control association study with a community-based sample, comprising 363 Caucasians and 72 African Americans (203 cases, 232...
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