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Integration of mutation and chromosomal damage endpoints into 28-day repeat dose toxicology studies.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Jun 2010

Dertinger Stephen D, Phonethepswath Souk, Franklin Dean, Weller Pamela, Torous Dorothea K, Bryce Steven M, Avlasevich Svetlana, Bemis Jeffrey C, Hyrien Ollivier, Palis James, MacGregor James T

Abstract excerpt

Two endpoints of genetic toxicity, mutation at the X-linked Pig-a gene and chromosomal damage in the form of micronucleated reticulocytes (MN-RETs), were evaluated in blood samples obtained from 28-day repeat-dosing studies typical of those employed in toxicity evaluations. Male Wistar Han rats were treated at 24-h intervals on days 1 through 28 with one of five prototypical genotoxicants: N-ethyl-N-nitrosourea,...

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Identifiers

PMID: 20202993
DOI: 10.1093/toxsci/kfq070
PMCID: PMC2871757

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CD59
RET

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Source receipt: pubmed, retrieved 7 Sept 2026.

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