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Parkinson disease–associatedLRRK2 G2019Stransgene disrupts marrow myelopoiesis and peripheral Th17 response

27 Jul 2017

Abstract excerpt

Parkinson's disease (PD) is a neurodegenerative disease, whereas Crohn's disease is an inflammatory bowel disease. Interestingly, polymorphisms in the LRRK2 gene have been identified as risk factors for both diseases. LRRK2 G2019S is the most prevalent mutation found in PD. To gain insights into the role of the LRRK2 G2019S gene on the development and activation of the immune system in the brain–gut axis, we...

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PMID: 28751472
DOI: 10.1189/jlb.1a0417-147rr

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