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Article

Ablation of the p16(INK4a) tumour suppressor reverses ageing phenotypes of klotho mice.

Nature communications - 29 Apr 2015

Sato Seidai, Kawamata Yuka, Takahashi Akiko, Imai Yoshinori, Hanyu Aki, Okuma Atsushi, Takasugi Masaki, Yamakoshi Kimi, Sorimachi Hiroyuki, Kanda Hiroaki, Ishikawa Yuichi, Sone Saburo, Nishioka Yasuhiko, Ohtani Naoko, Hara Eiji

Abstract excerpt

The p16(INK4a) tumour suppressor has an established role in the implementation of cellular senescence in stem/progenitor cells, which is thought to contribute to organismal ageing. However, since p16(INK4a) knockout mice die prematurely from cancer, whether p16(INK4a) reduces longevity remains un...

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Share to Aging
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Share to Cyclin-Dependent Kinase Inhibitor p16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Genes, p16

Share to Glucuronidase

Share to Klotho Proteins

Share to Mice, Inbred C57BL

Source

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Identifiers

PMID: 25923845
DOI: 10.1038/ncomms8035
PMCID: PMC4421814

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25923845-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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