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Article

Suppression of Aging in Mice by the Hormone Klotho

25 Aug 2005

Abstract excerpt

A defect in Klotho gene expression in mice accelerates the degeneration of multiple age-sensitive traits. Here, we show that overexpression of Klotho in mice extends life span. Klotho protein functions as a circulating hormone that binds to a cell-surface receptor and represses intracellular signals of insulin and insulin-like growth factor 1 (IGF1), an evolutionarily conserved mechanism for extending life span....

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Identifiers

PMID: 16123266
DOI: 10.1126/science.1112766

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