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Augmented Wnt Signaling in a Mammalian Model of Accelerated Aging

9 Aug 2007

Abstract excerpt

The contribution of stem and progenitor cell dysfunction and depletion in normal aging remains incompletely understood. We explored this concept in the Klotho mouse model of accelerated aging. Analysis of various tissues and organs from young Klotho mice revealed a decrease in stem cell number and an increase in progenitor cell senescence. Because klotho is a secreted protein, we postulated that klotho might...

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PMID: 17690294
DOI: 10.1126/science.1143578

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