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Article

NRF2 pathway activation attenuates ageing-related renal phenotypes due to α-klotho deficiency.

Journal of biochemistry - 11 May 2022

Zhao Mingyue, Murakami Shohei, Matsumaru Daisuke, Kawauchi Takeshi, Nabeshima Yo-Ichi, Motohashi Hozumi

Abstract excerpt

Oxidative stress is one of the major causes of the age-related functional decline in cells and tissues. The KEAP1-NRF2 system plays a central role in the regulation of redox balance, and NRF2 activation exerts antiageing effects by controlling oxidative stress in aged tissues. α-Klotho was identified as an ageing suppressor protein based on the premature ageing phenotypes of its mutant mice, and its expression is...

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PMID: 35137128
DOI: 10.1093/jb/mvac014

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