Article
Regulation of multiple ageing-like phenotypes by inducible klotho gene expression in klotho mutant mice.
Mechanisms of ageing and development - 1 Dec 2005
Masuda Hiroaki, Chikuda Hirotaka, Suga Tatsuo, Kawaguchi Hiroshi, Kuro-o Makoto
Abstract excerpt
Mice carrying a loss-of-function mutation in the klotho gene (KL(-/-) mice) develop ageing-like symptoms around 4 weeks after birth and suffer from multiple age-related disorders observed in humans, including osteoporosis, arteriosclerosis, and pulmonary emphysema. The klotho gene encodes a single-pass transmembrane protein that may function in signaling pathways that suppress ageing. To investigate the ability...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.