Article
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders.
Nature - 2 Nov 2011
Baker Darren J, Wijshake Tobias, Tchkonia Tamar, LeBrasseur Nathan K, Childs Bennett G, van de Sluis Bart, Kirkland James L, van Deursen Jan M
Abstract excerpt
Advanced age is the main risk factor for most chronic diseases and functional deficits in humans, but the fundamental mechanisms that drive ageing remain largely unknown, impeding the development of interventions that might delay or prevent age-related disorders and maximize healthy lifespan. Cellular senescence, which halts the proliferation of damaged or dysfunctional cells, is an important mechanism to...
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