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Article

Simultaneous loss of phospholipase Cδ1 and phospholipase Cδ3 causes cardiomyocyte apoptosis and cardiomyopathy.

Cell death & disease - 8 May 2014

Nakamura Y, Kanemaru K, Kojima R, Hashimoto Y, Marunouchi T, Oka N, Ogura T, Tanonaka K, Fukami K

Abstract excerpt

Phospholipase C (PLC) is a key enzyme in phosphoinositide turnover. Among 13 PLC isozymes, PLCδ1 and PLCδ3 share high sequence homology and similar tissue distribution, and are expected to have functional redundancy in many tissues. We previously reported that the simultaneous loss of PLCδ1 and PLCδ3 caused embryonic lethality because of excessive apoptosis and impaired vascularization of the placenta. Prenatal...

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Identifiers

PMID: 24810051
DOI: 10.1038/cddis.2014.181
PMCID: PMC4047916

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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