Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in mice

Abstract excerpt

Uterine decidualization, a process that occurs in response to embryo implantation, is critical for embryonic survival and thus is a key event for successful pregnancy. Here we show that the sphingolipid metabolic pathway is highly activated in the deciduum during pregnancy and disturbance of the pathway by disruption of sphingosine kinase (Sphk) genes causes defective decidualization with severely compromised...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Apelin-related biomedical research
• Share to Reproductive System and Pregnancy
• Share to Sphingolipid Metabolism and Signaling