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Article

Sec17 can trigger fusion of trans-SNARE paired membranes without Sec18.

Proceedings of the National Academy of Sciences of the United States of America - 5 May 2015

Zick Michael, Orr Amy, Schwartz Matthew L, Merz Alexey J, Wickner William T

Abstract excerpt

Sec17 [soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein; α-SNAP] and Sec18 (NSF) perform ATP-dependent disassembly of cis-SNARE complexes, liberating SNAREs for subsequent assembly of trans-complexes for fusion. A mutant of Sec17, with limited ability to stimulate Sec18, still strongly enhanced fusion when ample Sec18 was supplied, suggesting that Sec17 has additional functions. We used fusion...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25902545
DOI: 10.1073/pnas.1506409112
PMCID: PMC4426435

Genes

NSF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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