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Article

Double-Transmembrane Domain of SNAREs Decelerates the Fusion by Increasing the Protein-Lipid Mismatch.

Journal of molecular biology - 1 Jul 2023

Bu Bing, Tian Zhiqi, Li Dechang, Zhang Kai, Chen Wei, Ji Baohua, Diao Jiajie

Abstract excerpt

SNARE is the essential mediator of membrane fusion that highly relies on the molecular structure of SNAREs. For instance, the protein syntaxin-1 involved in neuronal SNAREs, has a single transmembrane domain (sTMD) leading to fast fusion, while the syntaxin 17 has a V-shape double TMDs (dTMDs), taking part in the autophagosome maturation. However, it is not clear how the TMD structure influences the fusion...

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Identifiers

PMID: 37030649
DOI: 10.1016/j.jmb.2023.168089
PMCID: PMC10247502

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