Article
Munc18-1 tuning of vesicle merger and fusion pore properties.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Jun 2011
Jorgacevski Jernej, Potokar Maja, Grilc Sonja, Kreft Marko, Liu Wei, Barclay Jeff W, Bückers Johanna, Medda Rebecca, Hell Stefan W, Parpura Vladimir, Burgoyne Robert D, Zorec Robert
Abstract excerpt
The release of hormones and neurotransmitters, mediated by regulated exocytosis, can be modified by regulation of the fusion pore. The fusion pore is considered stable and narrow initially, eventually leading to the complete merger of the vesicle and the plasma membranes. By using the high-resolution patch-clamp capacitance technique, we studied single vesicles and asked whether the Sec1/Munc18 proteins,...
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