Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sequential analysis of trans-SNARE formation in intracellular membrane fusion.

PLoS biology - 1 Jan 2012

Alpadi Kannan, Kulkarni Aditya, Comte Veronique, Reinhardt Monique, Schmidt Andrea, Namjoshi Sarita, Mayer Andreas, Peters Christopher

Abstract excerpt

SNARE complexes are required for membrane fusion in the endomembrane system. They contain coiled-coil bundles of four helices, three (Q(a), Q(b), and Q(c)) from target (t)-SNAREs and one (R) from the vesicular (v)-SNARE. NSF/Sec18 disrupts these cis-SNARE complexes, allowing reassembly of their subunits into trans-SNARE complexes and subsequent fusion. Studying these reactions in native yeast vacuoles, we found...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Intracellular Membranes
Share to Membrane Fusion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multiprotein Complexes

Share to Oxidation-Reduction

Share to Protein Stability

Share to rab GTP-Binding Proteins

Share to SNARE Proteins

Share to Vacuoles

Source

Open in PubMed Open full text

Identifiers

PMID: 22272185
DOI: 10.1371/journal.pbio.1001243
PMCID: PMC3260307

Genes

NSF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sequential analysis of trans-SNARE formation in intracellular membrane fusion.PMID 22272185Read ↗

Sec17 can trigger fusion of trans-SNARE paired membranes without Sec18.Semantic proximity Read ↗

Concerted auto-regulation in yeast endosomal t-SNAREs.Semantic proximity Read ↗

Three v-SNAREs and two t-SNAREs, present in a pentameric cis-SNARE complex on isolated vacuoles, are essential for homotypic fusion.Semantic proximity Read ↗

Selective activation of cognate SNAREpins by Sec1/Munc18 proteins.Semantic proximity Read ↗

A family of small coiled-coil-forming proteins functioning at the late endosome in yeast.Semantic proximity Read ↗

ATP-independent control of Vac8 palmitoylation by a SNARE subcomplex on yeast vacuoles.Semantic proximity Read ↗

Identification of genes affecting vacuole membrane fragmentation in Saccharomyces cerevisiae.Semantic proximity Read ↗

The trans-SNARE-regulating function of Munc18-1 is essential to synaptic exocytosis.Semantic proximity Read ↗

Importance of the N-terminal domain of the Qb-SNARE Vti1p for different membrane transport steps in the yeast endosomal system.Semantic proximity Read ↗

Ykt6 functionally overlaps with vacuolar and exocytic R-SNAREs in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

A novel SNARE complex implicated in vesicle fusion with the endoplasmic reticulum.Semantic proximity Read ↗

A Systematic Approach to Pair Secretory Cargo Receptors with Their Cargo Suggests a Mechanism for Cargo Selection by Erv14Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.