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Article

SNARE complex formation is triggered by Ca2+ and drives membrane fusion.

Cell - 16 Apr 1999

Chen Y A, Scales S J, Patel S M, Doung Y C, Scheller R H

Abstract excerpt

Neurotransmitter exocytosis, a process mediated by a core complex of syntaxin, SNAP-25, and VAMP (SNAREs), is inhibited by SNARE-cleaving neurotoxins. Botulinum neurotoxin E inhibition of norepinephrine release in permeabilized PC12 cells can be rescued by adding a 65 aa C-terminal fragment of SNAP-25 (S25-C). Mutations along the hydrophobic face of the S25-C helix result in SNARE complexes with different...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 10219238
DOI: 10.1016/s0092-8674(00)80727-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SNARE complex formation is triggered by Ca2+ and drives membrane fusion.PMID 10219238Read ↗

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