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Article

Distinct sets of SEC genes govern transport vesicle formation and fusion early in the secretory pathway.

Cell - 18 May 1990

Kaiser C A, Schekman R

Abstract excerpt

A vesicular intermediate in protein transport from the endoplasmic reticulum is detected in a subset of temperature-sensitive mutants blocked early in the yeast secretory pathway. By electron microscopy three of the mutants, sec18, sec17, and sec22, accumulate 50 nm vesicles at the nonpermissive temperature. Vesicle accumulation is blocked by the mutations sec12, sec13, sec16, and sec23 as shown by analysis of...

Topics

Alleles
Biological Transport
Cycloheximide
Cytoplasmic Granules
Endoplasmic Reticulum
Genes, Fungal
Golgi Apparatus
Intracellular Membranes
Membrane Fusion
Mutation
Saccharomyces cerevisiae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 2188733
DOI: 10.1016/0092-8674(90)90483-u

Genes

SEC13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2188733-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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