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Article

Selective activation of cognate SNAREpins by Sec1/Munc18 proteins.

Cell - 12 Jan 2007

Shen Jingshi, Tareste David C, Paumet Fabienne, Rothman James E, Melia Thomas J

Abstract excerpt

Sec1/Munc18 (SM) proteins are required for every step of intracellular membrane fusion, but their molecular mechanism of action has been unclear. In this work, we demonstrate a fundamental role of the SM protein: to act as a stimulatory subunit of its cognate SNARE fusion machinery. In a reconstituted system, mammalian SNARE pairs assemble between bilayers to drive a basal fusion reaction. Munc18-1/nSec1, a...

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Identifiers

PMID: 17218264
DOI: 10.1016/j.cell.2006.12.016

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Selective activation of cognate SNAREpins by Sec1/Munc18 proteins.PMID 17218264Read ↗

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