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Article

Geranylgeranylated SNAREs are dominant inhibitors of membrane fusion.

The Journal of cell biology - 16 Oct 2000

Grote E, Baba M, Ohsumi Y, Novick P J

Abstract excerpt

Exocytosis in yeast requires the assembly of the secretory vesicle soluble N-ethylmaleimide-sensitive factor attachment protein receptor (v-SNARE) Sncp and the plasma membrane t-SNAREs Ssop and Sec9p into a SNARE complex. High-level expression of mutant Snc1 or Sso2 proteins that have a COOH-terminal geranylgeranylation signal instead of a transmembrane domain inhibits exocytosis at a stage after vesicle docking....

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Identifiers

PMID: 11038190
DOI: 10.1083/jcb.151.2.453
PMCID: PMC2192637

Genes

GPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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