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Article

Role for RNA:DNA hybrids in origin-independent replication priming in a eukaryotic system.

Proceedings of the National Academy of Sciences of the United States of America - 5 May 2015

Stuckey Ruth, García-Rodríguez Néstor, Aguilera Andrés, Wellinger Ralf Erik

Abstract excerpt

DNA replication initiates at defined replication origins along eukaryotic chromosomes, ensuring complete genome duplication within a single S-phase. A key feature of replication origins is their ability to control the onset of DNA synthesis mediated by DNA polymerase-α and its intrinsic RNA primase activity. Here, we describe a novel origin-independent replication process that is mediated by transcription. RNA...

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Identifiers

PMID: 25902524
DOI: 10.1073/pnas.1501769112
PMCID: PMC4426422

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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