Article

A universal regulatory mechanism for prevention of replication restart from RNA:DNA hybrids

2026-02-27

Abstract excerpt

RNA:DNA hybrids form across all genomes. In vitro studies showed that these structures can be used to restart stalled replication forks, especially upon replication-transcription conflicts, however, this has not been tested in vivo . Here, we identify a mechanism that prevents replication restart from hybrids within cells. We identified the tRNA ligase, AsnRS, as a regulator of replication restart from hybrids a...

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Literature Corpus work: b68bdb8f-6a34-57bc-b004-4c95aee884c2
DOI: 10.64898/2026.02.26.708313

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