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Article

Chromatin Constrains the Initiation and Elongation of DNA Replication.

Molecular cell - 5 Jan 2017

Devbhandari Sujan, Jiang Jieqing, Kumar Charanya, Whitehouse Iestyn, Remus Dirk

Abstract excerpt

Eukaryotic chromosomal DNA is faithfully replicated in a complex series of cell-cycle-regulated events that are incompletely understood. Here we report the reconstitution of DNA replication free in solution with purified proteins from the budding yeast Saccharomyces cerevisiae. The system recapitulates regulated bidirectional origin activation; synthesis of leading and lagging strands by the three replicative DNA...

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Identifiers

PMID: 27989437
DOI: 10.1016/j.molcel.2016.10.035
PMCID: PMC5256687

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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