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Article

Sequencing the CHO DXB11 genome reveals regional variations in genomic stability and haploidy.

BMC genomics - 8 Mar 2015

Kaas Christian Schrøder, Kristensen Claus, Betenbaugh Michael J, Andersen Mikael Rørdam

Abstract excerpt

BACKGROUND: The DHFR negative CHO DXB11 cell line (also known as DUX-B11 and DUKX) was historically the first CHO cell line to be used for large scale production of heterologous proteins and is still used for production of a number of complex proteins. RESULTS: Here we present the genomic sequence of the CHO DXB11 genome sequenced to a depth of 33x. Overall a significant genomic drift was seen favoring GC → AT...

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Identifiers

PMID: 25887056
DOI: 10.1186/s12864-015-1391-x
PMCID: PMC4359788

Genes

DHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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