Article
Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome.
Nature biotechnology - 1 Aug 2013
Lewis Nathan E, Liu Xin, Li Yuxiang, Nagarajan Harish, Yerganian George, O'Brien Edward, Bordbar Aarash, Roth Anne M, Rosenbloom Jeffrey, Bian Chao, Xie Min, Chen Wenbin, Li Ning, Baycin-Hizal Deniz, Latif Haythem, Forster Jochen, Betenbaugh Michael J, Famili Iman, Xu Xun, Wang Jun, Palsson Bernhard O
Abstract excerpt
Chinese hamster ovary (CHO) cells, first isolated in 1957, are the preferred production host for many therapeutic proteins. Although genetic heterogeneity among CHO cell lines has been well documented, a systematic, nucleotide-resolution characterization of their genotypic differences has been stymied by the lack of a unifying genomic resource for CHO cells. Here we report a 2.4-Gb draft genome sequence of a...
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