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How to train your cell - Towards controlling phenotypes by harnessing the epigenome of Chinese hamster ovary production cell lines.

Biotechnology advances - 1 Jan 2000

Marx Nicolas, Eisenhut Peter, Weinguny Marcus, Klanert Gerald, Borth Nicole

Abstract excerpt

Recent advances in omics technologies and the broad availability of big datasets have revolutionized our understanding of Chinese hamster ovary cells in their role as the most prevalent host for production of complex biopharmaceuticals. In consequence, our perception of this "workhorse of the biopharmaceutical industry" has successively shifted from that of a nicely working, but unknown recombinant protein...

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CHO Cells
Cricetinae
Cricetulus
Epigenesis, Genetic
Epigenome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombinant Proteins

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PMID: 35149147
DOI: 10.1016/j.biotechadv.2022.107924

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