Article

<i>In vitro</i> evolution and whole genome analysis to study chemotherapy drug resistance in haploid human cells

2020-03-18

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> In vitro evolution and whole genome analysis has proven to be a powerful method for studying the mechanism of action of small molecules in many haploid microbes but has generally not been applied to human cell lines in part because their diploid state complicates the identification of variants that confer drug resistance. To determine if haploid human cell could be used in M...

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Literature Corpus work: 17e55d97-b6b2-5f32-82ec-abe2a4258f74
DOI: 10.1101/2020.03.17.982181

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