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Article

A platform for functional assessment of large variant libraries in mammalian cells.

Nucleic acids research - 20 Jun 2017

Matreyek Kenneth A, Stephany Jason J, Fowler Douglas M

Abstract excerpt

Sequencing-based, massively parallel genetic assays have revolutionized our ability to quantify the relationship between many genotypes and a phenotype of interest. Unfortunately, variant library expression platforms in mammalian cells are far from ideal, hindering the study of human gene variants in their physiologically relevant cellular contexts. Here, we describe a platform for phenotyping variant libraries...

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Identifiers

PMID: 28335006
DOI: 10.1093/nar/gkx183
PMCID: PMC5499817

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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