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Article

A comparative genomic hybridization approach to study gene copy number variations among Chinese hamster cell lines.

Biotechnology and bioengineering - 1 Aug 2017

Vishwanathan Nandita, Bandyopadhyay Arpan, Fu Hsu-Yuan, Johnson Kathryn C, Springer Nathan M, Hu Wei-Shou

Abstract excerpt

Chinese Hamster Ovary (CHO) cells are aneuploid in nature. The genome of recombinant protein producing CHO cell lines continuously undergoes changes in its structure and organization. We analyzed nine cell lines, including parental cell lines, using a comparative genomic hybridization (CGH) array focused on gene-containing regions. The comparison of CGH with copy-number estimates from sequencing data showed good...

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PMID: 28409824
DOI: 10.1002/bit.26311

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