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Ultra-deep next generation mitochondrial genome sequencing reveals widespread heteroplasmy in Chinese hamster ovary cells.

Metabolic engineering - 1 May 2017

Kelly Paul S, Clarke Colin, Costello Alan, Monger Craig, Meiller Justine, Dhiman Heena, Borth Nicole, Betenbaugh Michael J, Clynes Martin, Barron Niall

Abstract excerpt

Recent sequencing of the Chinese hamster ovary (CHO) cell and Chinese hamster genomes has dramatically advanced our ability to understand the biology of these mammalian cell factories. In this study, we focus on the powerhouse of the CHO cell, the mitochondrion. Utilizing a high-resolution next generation sequencing approach we sequenced the Chinese hamster mitochondrial genome for the first time and surveyed the...

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PMID: 28188893
DOI: 10.1016/j.ymben.2017.02.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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