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Article

Comprehensive genome and epigenome characterization of CHO cells in response to evolutionary pressures and over time.

Biotechnology and bioengineering - 1 Oct 2016

Feichtinger Julia, Hernández Inmaculada, Fischer Christoph, Hanscho Michael, Auer Norbert, Hackl Matthias, Jadhav Vaibhav, Baumann Martina, Krempl Peter M, Schmidl Christian, Farlik Matthias, Schuster Michael, Merkel Angelika, Sommer Andreas, Heath Simon, Rico Daniel, Bock Christoph, Thallinger Gerhard G, Borth Nicole

Abstract excerpt

The most striking characteristic of CHO cells is their adaptability, which enables efficient production of proteins as well as growth under a variety of culture conditions, but also results in genomic and phenotypic instability. To investigate the relative contribution of genomic and epigenetic modifications towards phenotype evolution, comprehensive genome and epigenome data are presented for six related CHO...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27072894
DOI: 10.1002/bit.25990
PMCID: PMC5006888

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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