Article
Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis.
Genes & development - 1 May 2015
Rasmussen Kasper D, Jia Guangshuai, Johansen Jens V, Pedersen Marianne T, Rapin Nicolas, Bagger Frederik O, Porse Bo T, Bernard Olivier A, Christensen Jesper, Helin Kristian
Abstract excerpt
DNA methylation is tightly regulated throughout mammalian development, and altered DNA methylation patterns are a general hallmark of cancer. The methylcytosine dioxygenase TET2 is frequently mutated in hematological disorders, including acute myeloid leukemia (AML), and has been suggested to protect CG dinucleotide (CpG) islands and promoters from aberrant DNA methylation. In this study, we present a novel...
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