Article
An extensive network of TET2-targeting MicroRNAs regulates malignant hematopoiesis.
Cell reports - 31 Oct 2013
Cheng Jijun, Guo Shangqin, Chen Suning, Mastriano Stephen J, Liu Chaochun, D'Alessio Ana C, Hysolli Eriona, Guo Yanwen, Yao Hong, Megyola Cynthia M, Li Dan, Liu Jun, Pan Wen, Roden Christine A, Zhou Xiao-Ling, Heydari Kartoosh, Chen Jianjun, Park In-Hyun, Ding Ye, Zhang Yi, Lu Jun
Abstract excerpt
The Ten-Eleven-Translocation 2 (TET2) gene, which oxidates 5-methylcytosine in DNA to 5-hydroxylmethylcytosine (5hmC), is a key tumor suppressor frequently mutated in hematopoietic malignancies. However, the molecular regulation of TET2 expression is poorly understood. We show that TET2 is under extensive microRNA (miRNA) regulation, and such TET2 targeting is an important pathogenic mechanism in hematopoietic...
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