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TGF<i>β</i>Signaling in Tumor Initiation, Epithelial-to-Mesenchymal Transition, and Metastasis

1 Jan 2015

Abstract excerpt

Retaining the delicate balance in cell signaling activity is a prerequisite for the maintenance of physiological tissue homeostasis. Transforming growth factor-beta (TGFβ) signaling is an essential pathway that plays crucial roles during embryonic development as well as in adult tissues. Aberrant TGFβ signaling activity regulates tumor progression in a cancer cell-autonomous or non-cell-autonomous fashion and...

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PMID: 25883652
DOI: 10.1155/2015/587193

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