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Article

TGF-β signaling and epithelial–mesenchymal transition in cancer progression

28 Nov 2012

Abstract excerpt

PURPOSE OF REVIEW: TGF-β acts as a potent driver of cancer progression through the induction of epithelial-mesenchymal transition (EMT), in which epithelial cells acquire mesenchymal phenotype, leading to enhanced motility and invasion. Recent reports highlight the fundamental roles of TGF-β-induced EMT in multiple aspects of cancer progression. In this review, we focus on the novel insights into the roles of...

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PMID: 23197193
DOI: 10.1097/cco.0b013e32835b6371

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