The Role of TGF-β Signaling Pathways in Cancer and Its Potential as a Therapeutic Target

doi:10.1155/2021/6675208

Article

The Role of TGF-β Signaling Pathways in Cancer and Its Potential as a Therapeutic Target

22 Jul 2021

Abstract excerpt

The transforming growth factor-β (TGF-β) signaling pathway mediates various biological functions, and its dysregulation is closely related to the occurrence of malignant tumors. However, the role of TGF-β signaling in tumorigenesis and development is complex and contradictory. On the one hand, TGF-β signaling can exert antitumor effects by inhibiting proliferation or inducing apoptosis of cancer cells. On the...

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