Transforming growth factor‐β signaling: Tumorigenesis and targeting for cancer therapy

doi:10.1002/jcp.27955

Article

Transforming growth factor‐β signaling: Tumorigenesis and targeting for cancer therapy

7 Dec 2018

Abstract excerpt

Transforming growth factor (TGF)-β is a multitasking cytokine such that its aberrant expression is related to cancer progression and metastasis. TGF-β is produced by a variety of cells within the tumor microenvironment (TME), and it is responsible for regulation of the activity of cells within this milieu. TGF-β is a main inducer of epithelial-mesenchymal transition (EMT), immune evasion, and metastasis during...

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