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Article

Targeting the TGFβ pathway for cancer therapy

6 Nov 2014

Abstract excerpt

The TGFβ signaling pathway has pleiotropic functions regulating cell growth, differentiation, apoptosis, motility and invasion, extracellular matrix production, angiogenesis, and immune response. TGFβ signaling deregulation is frequent in tumors and has crucial roles in tumor initiation, development and metastasis. TGFβ signaling inhibition is an emerging strategy for cancer therapy. The role of the TGFβ pathway...

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PMID: 25444759
DOI: 10.1016/j.pharmthera.2014.11.001

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